The Reverend Cotton Marcus had performed more exorcisms than he could remember before he visited the Louisiana farm of Louis Sweetzer. That would be a day he wouldn't soon forget. The last person Lious Sweetzer ever thought he would invite to his farm was an exorcist. But his young daughter Nell had been acting so strange. He could think of no other explanation for her behavior than possession by demons. But many long years of attending to those with questionable spiritual infestations has left Cotton a broken man. The faith he once proudly held up as a sheild against evil had deserted him long ago.

The film follows the action of four Charlestown, Massachusetts bank robbers as they are pursued by law enforcement. Affleck plays a professional thief who falls for a bank manager (Rebecca Hall) after a dangerous heist. He struggles with this newfound relationship whilst evading a tenacious FBI agent (Jon Hamm) looking to catch him and his crew before they rob another bank.

Kate (Hayden Panettiere) and Humphrey (Justin Long) are two wolves from the same pack in Canada's Jasper National Park, but on opposite ends of the social order. Kate, daughter of the main alpha male, is herself an Alpha and does what one should: taking her duty and commitment to the pack seriously. Humphrey, on the other hand, is an Omega wolf, the lowest of the pack, and spends his days making jokes and playing about with his other Omega friends. Despite his low rank in the pack, Humphrey has a crush on Kate. One day, Kate is arranged to mate with the Alpha male of a rival pack to preserve peace. However, both Kate and Humphrey are sedated and taken far away from home to the Sawtooth National Recreation Area in Idaho where they are expected to repopulate their species. Instead, the two wolves who should never find themselves socializing with each other embark on a journey together to return home and save their pack before relations between rival packs come to a boil.