Kate (Hayden Panettiere) and Humphrey (Justin Long) are two wolves from the same pack in Canada's Jasper National Park, but on opposite ends of the social order. Kate, daughter of the main alpha male, is herself an Alpha and does what one should: taking her duty and commitment to the pack seriously. Humphrey, on the other hand, is an Omega wolf, the lowest of the pack, and spends his days making jokes and playing about with his other Omega friends. Despite his low rank in the pack, Humphrey has a crush on Kate. One day, Kate is arranged to mate with the Alpha male of a rival pack to preserve peace. However, both Kate and Humphrey are sedated and taken far away from home to the Sawtooth National Recreation Area in Idaho where they are expected to repopulate their species. Instead, the two wolves who should never find themselves socializing with each other embark on a journey together to return home and save their pack before relations between rival packs come to a boil.